Nuclear Medicine and Preclinical Imaging Systems
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nanoScan SPECT/MRI


The first integrated preclinical whole-body SPECT/MRI with 275 μm SPECT and 100 μm MRI spatial resolutionIntegrated whole-body preclinical SPECT/MRI system for in-line multi-modality preclinical imaging

Summary of Key Benefits
  • Continuous leadership in preclinical SPECT technology; using decades of expertise
    • Non-multiplexed M3pinhole™ apertures, up to 100 pinholes; easily replaceable; whole-body mouse and rat collimator
    • Exceptional performance: Up to 10,000 cps/MBq sensitivity @ sub mm resolution / Up to 0.275 mm resolution
    • Ultra fast 4D/5D list mode dynamic imaging by static or rotational modes with stationary and helical scans (please contact us for configuration options)
    • The system applies both CT-based attenuation and scatter correction – especially important for quantitative low-energy isotope studies
    • A selected configuration of the Mediso small animal SPECT system can image mice and monkeys (with parallel hole collimators)
  • No compromise in the imaging performance: negligible fringe field of the permanent magnet ensures the unique high performance of SPECT subsystem
    • 275 µm spatial resolution with Tera-Tomo™ 3D SPECT reconstruction engine – on the fly Monte Carlo based running on multiple GPUs
    • Absolute quantification accuracy over 97%
    • True stationary data registration allows fast dynamic analysis with SPECT
    • Multiple isotope imaging (unlimited number of energy windows)
  • Versatile soft tissue contrast for the best Volume of Interest definitions
    • Determine the volume of tumours: for characterising the size, vascularisation and heterogeneity
    • Detailed structural information in the brain revealing exact distribution of neurological SPECT tracers
  • Compact and easy-to-use design
    • minimal special training required
    • no need for long calibrations after start-up
    • no waiting time between PET and MRI acquisitions
    • quick and easy installation
CNS: Benzodiazepine receptors in mouse - SPECT/MRI image of a mouse injected with 7.4 MBq of 123I-NNC13-82431, 3 h post injection, during 30 minutes
Summary of Key Benefits for SPECT
  • The complete system is designed in house by Mediso
    • Mediso Ultra High Performance (UHP) Detector
      • More than doubled crystal density: 50% larger detector area & 50% thicker crystal
      • Fully digital premium electronics: digital 1 ADC/PMT non-Anger detector electronics
      • 4 NaI(Tl) single 28x28cm crystal detectors; crystal thickness 9.5mm; detector FOV 27x27cm
      • Number of photomultiplier tubes: 144 (for 4 heads)
      • Fully digital: digital 1 ADC/PMT non-Anger detector electronics
    • Mediso multi-focal multi-size multiple pinhole apertures (M3-pinhole™)
      • Rectangular apertures have variable aperture size in one plate
      • Multifocal geometry
      • Non-overlapping projections
      • Select the appropriate aperture for the application: whole-body mouse, whole-body rat, ultra-high sensitivity or resolution apertures
      • Fast and easy replacement of apertures
Summary of Key Benefits for high-performance, compact MRI subsystem

MRI from Aspect Imaging

Compact permanent 1T Magnet

  • No active fringe magnetic field - The PET/MRI does not require any special shielding facility spacious cry-cooling sub-equipments and it can be rapidly shifter to a new area in the lab. It can be placed anywhere in the research facility even next to other sensitive imaging systems
  • Virtually maintenance-free
  • No dedicated facilities or shielded rooms
  • No isolation from other metal objects required
  • Simple siting
  • No dedicated power supplies
  • No special cooling required
  • Easy-to-use software, simple workflow and pre-programmed sequences – lab technician with no prior MRI or imaging experience can quickly master the platform and perform highly effective MR-based imaging experiments
  • The magnet operates at 1 Tesla field strength. This is the most effective field strength and frequency in which to perform gadolinium-based contrast agent imaging due to the nature of the relaxivity curves of such agents
  • Silent operation by whispering gradients – animals can be kept in the same room and depth of anesthesia can be kept at a minimum
  • Image resolution 100 μm in-vivo (ex-vivo spatial resolution <100 µm)
Advantages of the Compact and Integrated System
  • No loss of information due to reorientation
  • Attenuation & Scatter Correction based on MRI data
  • Common gantry and single image coordinate system for both modalities
  • Common integrated acquisition software
  • Integrated and optimized SPECT/MRI acquisition protocols
  • SPECT acquisition and reconstruction range selection based on MRI images
  • Whole-body MRI imaging with up to 280 mm extended axial field of view
  • Unequivocally co-registered MRI volume as anatomical reference for SPECT studies
  • ECG and Respiratory gated imaging for both SPECT and MRI modalities as an option
Why Integrated?

Would you buy stand-alone SPECT and CT systems? Why would an integrated SPECT/MRI be different?
Want to achieve reproducible, sub-millimetre co-registered fusion of your modalities?

Due to the high level of integration of the nanoScan SPECT/MRI, there is no loss of information caused by reorientation and co-registration of images acquired on standalone systems.

This design allows accurate attenuation and scatter correction based on MRI datasets which is not possible with standalone or separated systems

(1) due to the inevitable misalignment of the object caused by manual positioning and

(2) due to lack of integration of SPECT reconstruction and MRI data acquisition.

Automatic co-registration is ensured by single, integrated acquisition software used by the nanoScan SPECT/MRI imager. Importantly, precise positioning and automatic gantry movements enable multiple bed position MRI acquisitions covering the entire body length of a mouse and rat.

The temporal correlation is quasi-simultaneous: users do not need to spend time with moving the animal from one imager to the other or even moving it from one room to another. Switching between SPECT and MRI acquisitions has never been so quick and easy.

Considering the above mentioned advantages of the integrated nanoScan SPECT/MRI system, it is not surprising that throughput is high: acquiring a SPECT/MRI image will not take longer than a SPECT/CT with a dedicated SPECT/CT imager.

nanoScan SPECT/MRI uses the permanent magnet technology of Aspect Imaging which does not require any special cooling (ie. No cryogens or helium), plumbing, or auxiliary power supplies.  These features significantly reduce operating costs, require far less maintenance and allow quick and easy installation with minimal demand on the laboratory resources. It has a small footprint, it is even compatible with any laboratory and personal electronics equipment such as mobile phones and laptops.

 

Summary of Key Benefits for high-performance, compact MRI subsystem

MRI from Aspect Imaging

Compact permanent 1T Magnet

  • No active fringe magnetic field - The PET/MRI does not require any special shielding facility spacious cry-cooling sub-equipments and it can be rapidly shifter to a new area in the lab. It can be placed anywhere in the research facility even next to other sensitive imaging systems
  • Virtually maintenance-free
  • No dedicated facilities or shielded rooms
  • No isolation from other metal objects required
  • Simple siting
  • No dedicated power supplies
  • No special cooling required
  • Easy-to-use software, simple workflow and pre-programmed sequences – lab technician with no prior MRI or imaging experience can quickly master the platform and perform highly effective MR-based imaging experiments
  • The magnet operates at 1 Tesla field strength. This is the most effective field strength and frequency in which to perform gadolinium-based contrast agent imaging due to the nature of the relaxivity curves of such agents
  • Silent operation by whispering gradients – animals can be kept in the same room and depth of anesthesia can be kept at a minimum
  • Image resolution 100 μm in-vivo (ex-vivo spatial resolution <100 µm)