Nuclear Medicine and Preclinical Imaging Systems
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nanoScan PET/MRI

The first integrated preclinical whole-body PET/MRI with 700 μm PET and 100 μm MRI spatial resolutionIntegrated whole-body preclinical PET/MRI system for in-line multi-modality preclinical imaging

Summary of Key Benefits
  • No compromise in imaging performance: negligible fringe field of termanent magnet ensures the unique high performance of the PET subsystem
    • 700 µm spatial resolution with Tera-Tomo™ 3D PET reconstruction engine with Full Detector Modeling
    • Absolute quantification accuracy over 97%
  • Versatile soft tissue contrast for the best Volume of Interest definitions
    • Determine the volume of tumours: for characterising the size, vascularisation and heterogeneity
    • Detailed structural information in the brain revealing exact distribution of neurological PET tracers
  • Compact and easy-to-use design
    • minimal special training required
    • no need for long calibrations after start-up
    • no waiting time between PET and MRI acquisitions
    • quick and easy installation
Selected Features for PET subsystem
  • Superior PET detector characteristics:
    • High-density, ultra-small detectors in tight packing with finest LYSO detector elements in industry with smallest pitch
    • Increased crystal thickness for highest sensitivity
  • Measure even the finest details: Tera-Tomo™ 3D PET reconstruction engine brings PET resolution close to the physical limits with outstanding quantification and increased signal recovery and signal-to-noise ratio:
    • Features Monte Carlo system matrix modeling and Depth of Interaction correction; incorporates attenuation, scatter, positron range, random and dead time corrections
    • Reconstruction running on multiple GPUs (Graphical Processing Units) delivering shorter computation time
  • Perform Acquisition and Reconstruction simultaneously with the powerful workstations including DICOM server and multi-modality display and analysis suite
Summary of Key Benefits for high-performance, compact MRI subsystem

MRI from Aspect Imaging

Compact permanent 1T Magnet

  • No active fringe magnetic field - The PET/MRI does not require any special shielding facility spacious cry-cooling sub-equipments and it can be rapidly shifter to a new area in the lab. It can be placed anywhere in the research facility even next to other sensitive imaging systems
  • Virtually maintenance-free
  • No dedicated facilities or shielded rooms
  • No isolation from other metal objects required
  • Simple siting
  • No dedicated power supplies
  • No special cooling required
  • Easy-to-use software, simple workflow and pre-programmed sequences – lab technician with no prior MRI or imaging experience can quickly master the platform and perform highly effective MR-based imaging experiments
  • The magnet operates at 1 Tesla field strength. This is the most effective field strength and frequency in which to perform gadolinium-based contrast agent imaging due to the nature of the relaxivity curves of such agents
  • Silent operation by whispering gradients – animals can be kept in the same room and depth of anesthesia can be kept at a minimum
  • Image resolution 100 μm in-vivo (ex-vivo spatial resolution <100 µm)
Imaging Performance with Tera-Tomo 3D PET Reconstruction Engine

Advantages of the Compact and Integrated System
  • No loss of information due to reorientation
  • Attenuation & Scatter Correction based on MRI data
  • Common gantry and single image coordinate system for both modalities
  • Common integrated acquisition software
  • Integrated and optimized PET/MRI acquisition protocols
  • PET acquisition and reconstruction range selection based on MRI images
  • Whole-body MRI imaging with up to 240 mm extended axial field of view
  • Unequivocally co-registered MRI volume as anatomical reference for PET studies
  • ECG and Respiratory gated imaging for both PET and MRI modalities as an option
Why Integrated?

Would you buy stand-alone PET and CT systems? Why would an integrated PET/MRI be different?
Want to achieve reproducible, sub-millimetre co-registered fusion of your modalities?

Due to the high level of integration of the nanoScan PET/MRI, there is no loss of information caused by reorientation and co-registration of images acquired on standalone systems.

This design allows accurate attenuation and scatter correction based on MRI datasets which is not possible with standalone or separated systems

(1) due to the inevitable misalignment of the object caused by manual positioning and

(2) due to lack of integration of PET reconstruction and MRI data acquisition.

Automatic co-registration is ensured by single, integrated acquisition software used by the nanoScan PET/MRI imager. Importantly, precise positioning and automatic gantry movements enable multiple bed position MRI acquisitions covering the entire body length of a mouse and rat.

The temporal correlation is quasi-simultaneous: users do not need to spend time with moving the animal from one imager to the other or even moving it from one room to another. Switching between PET and MRI acquisitions has never been so quick and easy.

Considering the above mentioned advantages of the integrated nanoScan PET/MRI system, it is not surprising that throughput is high: Acquiring a PET/MRI image will not take longer than a PET/CT with a dedicated PET/CT imager.

nanoScan PET/MRI uses the permanent magnet technology of Aspect Imaging which does not require any special cooling (ie. No cryogens or helium), plumbing, or auxiliary power supplies.  These features significantly reduce operating costs, require far less maintenance and allow quick and easy installation with minimal demand on the laboratory resources. It has a small footprint, it is even compatible with any laboratory and personal electronics equipment such as mobile phones and laptops.